Projects from PD Dr. Adrian Keller
Ordered DNA origami lattices on silicon surfaces for molecular lithography
While the use of individual DNA origami nanostructures in the molecular lithography fabrication of functional metal nanostructures is well-established, the application of ordered DNA origami lattices as lithography masks faces several challenges. In the first phase of this project, we demonstrated the successful assembly of hexagonal and fishnet ...
Duration: 02/2026 - 01/2029
Next Generation Molecular Data Storage
Current long-term archival media (such as tape and disk) have several issues, the most important one being that they
are short lived (up to 5-10 years) forcing data to be copied between storage media every few years in a costly process
which also produces considerable electronic waste. Longer-lasting media are desperately needed and DNA oligos have ...
Duration: 10/2023 - 09/2026
Ordered DNA origami lattices on silicon surfaces for molecular lithography
DNA origami nanostructures have
become widely employed templates for the synthesis of functional materials.
Among the numerous methods reported in literature, molecular lithography has
proven particularly versatile because it enables the transfer of the nanoscale
DNA origami shape into almost arbitrary inorganic materials. Here, the DNA
origami ...
Duration: 03/2022 - 03/2025
Molecular mechanisms of the interaction of chaotropic salts with natural and artificial DNA structures
Due to their great versatility which enables
the spatially selective immobilization of biomolecules with nanometer precision,
DNA origami nanostructures are increasingly used substrates for the single-molecule
investigation of various biochemical and biophysical processes. In these
applications, the DNA origami substrates not only provide high ...
Duration: 01/2020 - 04/2023
Influence of periodic nanoscale ripple patterns on titanium surfaces on the osteogenic differentiation of human mesenchymal stem cells in combination with chemical and biological surface modifications (NanoTune)
The influence of anisotropic, ordered surface
topographies at the low nanometer level on the behavior of human mesenchymal stem cells (hMSC) is thus far
insufficiently investigated and poorly understood. Yet topographies with
vertical dimensions in the sub-10 nm range and lateral dimensions of the order
few 10 nm exhibit high potential to ...
Duration: 01/2018 - 07/2021
Single-molecule studies on DNA origami substrates
The DNA origami technique enables the rapid, high-yield assembly of
arbitrarily shaped DNA nanostructures while providing an
extraordinary degree of spatial and structural control. These nanostructures can be used as substrates for the precise
arrangement of single molecules into well-defined assemblies which
allows the visualization of chemical ...
Duration: 08/2015 - 05/2019